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Role of FAM173b in regulation of inflammatory pain

Friday 8 January 2016

Tissue damage and inflammation is often associated with pain. However, pain often persists even after recovery of inflammation/damage. As such more than 20% of the total population suffers from chronic pain that is very difficult to treat. We have identified a novel protein, FAM173b, key in the regulation of inflammatory pain. We identified this protein as a lysine-specific methyltransferase in mitochondria that affects mitochondrial functioning in sensory neurons ultimately leading to the activation of microglia, the macrophages of the central nervous system. In this project we aim at identifying downstream target of FAM173b and elucidate how FAM173b promotes pain through the activation of microglia with the ultimate aim to develop novel compounds to target this protein for the treatment of pain.

Techniques: Cell culture, cloning, in vivo virus-mediated overexpression, virus production, ELISA, Western Bot, RNA isolation, RT-PCR, cloning, sequencing, immune-precipitation, co-immuno-precipitation, animal research possible

Duration: 6-9 months

Contact: Dr. Niels Eijkelkamp: N.Eijkelkamp@umcutrecht.nl