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Institute for Risk Assessment Sciences

Tuesday 5 March 2013

The Immunotoxicology group
The Immunotoxicology group examines fundamental processes involved in immunosensitization and inflammatory responses by various agents, including drugs, environmental chemicals/pollutants and food components. Knowledge obtained will help to define early indicators of immunosensitizing potential of compounds (e.g. pharmaceuticals or new foods) that can be included in new and existing predictive models. In addition, this knowledge also contributes to development of prophylactic or therapeutic measures.

Ongoing projects:
1. Therapeutic approaches for food allergy
2. Mechanisms of drug hypersensitivity and immune-mediated liver injury

Current research group:
Raymond Pieters (Associate professor, Group Leader)
Marianne Bol-Schoenmakers (Scientist)
Joost Smit (Scientist)
Lydia Kwast (PhD student)
Veronica Schulz (PhD student)
Rob Bleumink (Technician)
Manon van Roest (Technician)
Laura Kruijssen (Technician)

Key Publications:
Schulz VJ, van Roest M, Bol-Schoenmakers M, van Duursen MB, van den Berg M, Pieters RH, Smit JJ.
Aryl hydrocarbon receptor activation affects the dendritic cell phenotype and function during allergic sensitization. Immunobiology. 2013 Feb 1.

Schulz VJ, Smit JJ, Bol-Schoenmakers M, Duursen MB, van den Berg M, Pieters RH. Activation of the aryl hydrocarbon receptor reduces the number of precursor and effector T cells, but preserves thymic CD4(+)CD25(+)Foxp3(+) regulatory T cells. Toxicol Lett. 2012, 215, 100-109.

Smit JJ, Willemsen K, Hassing I, Fiechter D, Storm G, van Bloois L, Leusen JH, Pennings M, Zaiss D, Pieters RH. Contribution of classic and alternative effector pathways in peanut-induced anaphylactic responses. PLoS One. 2011. 6:e28917.

Smit JJ, Bol-Schoenmakers M, Hassing I, Fiechter D, Boon L, Bleumink R, Pieters RH. The role of intestinal dendritic cells subsets in the establishment of food allergy. Clin Exp Allergy. 2011. 41: 890-8.

Kwast LM, Fiechter D, Hassing I, Bleumink R, Boon L, Ludwig IS, Pieters RH. Oral exposure to drugs with immune-adjuvant potential induces hypersensitivity responses to the reporter antigen TNP-OVA. Toxicol Sci. 2011 Jun;121:312-9.

Bol-Schoenmakers M, Marcondes Rezende M, Bleumink R, Boon L, Man S, Hassing I, Fiechter D, Pieters R, Smit JJ. Regulation by intestinal γδ T cells during establishment of food allergic sensitization in mice. Allergy. 2010. 66:331-40

Bol-Schoenmakers M, Bleumink R, Marcondes Rezende M, Mouser E, Hassing I, Ludwig I, Smit JJ, Pieters RH. Diclofenac enhances allergic responses in a mouse peanut allergy model. Clin Exp Allergy. 2010. 41:424-33


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