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Human IAPP aggregation and islet β-cell failure in type 2 diabetes mellitus, role of chronic islet inflammation

Tuesday 7 April 2015

Human IAPP aggregation and islet β-cell failure in type 2 diabetes mellitus, role of chronic islet inflammation
Type 2 diabetes mellitus (T2DM) is characterized by impaired insulin action and impaired insulin production by the pancreatic islet β-cells (β-cell failure). T2DM is characterized histopathologically by protein deposits in the pancreatic islets (“islet amyloid”). This amyloid is mainly composed of the β-cell protein Islet amyloid Polypeptide (IAPP). Islet amyloid formation is associated with dysfunction and death of the insulin-producing islet β-cells. Current research is focussed on the mechanism(s) of hIAPP-mediated β-cell failure, notably involving chronic inflammation of the pancreatic islets.

Techniques: cell culture; immunohistochemistry; image analysis; DNA- and RNA isolation; RT qPCR; pancreatic islet isolation; transgenic mice

Internships are possible for 6-9 months.
For more information: Dr. Jo Höppener J.W.M.Hoeppener@umcutrecht.nl, 088 7554987