Wednesday 14 January 2015
Follicular Dendritic Cells: dynamic antigen libraries
Promotor: Prof. dr. J.A.G. van Strijp
Defence: 14 January 2015
Follicular dendritic cells (FDCs) are essential for high-affinity antibody production and for the development of B cell memory. Historically, FDCs have been characterized as ‘accessory’ cells that passively support germinal centre (GC) responses. However, recent observations suggest that FDCs actively shape humoral immunity. In this dissertation, I discuss recent findings concerning the antigen acquisition and retention functions of FDCs, and relevant implications for protective immunity. Furthermore, I describe the roles of FDCs within GCs in secondary lymphoid organs and discuss FDC development within this dynamic environment. Finally, I discuss how a better understanding of FDCs could facilitate the design of next-generation vaccines.