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Biology of Disease - Immunity and Infection

Monday 12 March 2012

Time cost: 2 weeks
Period: week 37 + 38

Course aims & description
Starting with clinical cases, the pathophysiology of infectious and immune diseases will be presented. New concepts and therapies will be discussed. To obtain credits (3 ects) several short presentations have to be given and active participation is required.

Introductory lectures on the topic of the day will be followed by self-study (mainly in groups) and tutorials in which participants will present the results of their peers.

After completing the course the student is able to...
1. apply basic immunology knowledge in order to explain clinical signs of patients with primary immunodeficiencies.
2. describe the principles of role of dendritic cells in starting the specific immune response, their receptor composition and is able to apply this to tumor immunology and infectious diseases
3. name cells of the innate immune response, their place in evolution of the immune system and their role in hyperreactions against non-infectious material
4. name the basic principles of transplantation, especially the clinical aspects and problems as well as therapeutical options linked to bone marrow /stem cell transplantation.
5. describe the basics of tolerance induction and can discuss the multiple factors involved in the development of autoimmune diseases based on the available literature.
6. describe the replication cycle of EBV, a member of herpesviridae, in detail and can apply the knowledge about primary infection, latency and reactivation and immune evasion to several associated diseases.
7. describe the principles of pathogenesis of atopic dermatitis and the clinical signs associated and can propose a promising target for future therapy,
8. describe the concepts of pathogenesis of meningitis and sepsis and the role of pattern recognition receptors and cytokines in this process.

Topics include:
• Clinical case studies on primary immunodeficiencies and infections.
• Dendritic cells and their central role in starting specific immune responses
• Transplantation – clinical aspects, transplantation problems
• Autoimmune diseases
• Viro-immunological aspects of herperviridae infections & associated diseases
• Pathology of hyperactivity of the innate immune response
• Meningitis – disease caused by different pathogens
• Patients and pathogenesis of atopic dermatitis

Literature / study material used
Primary literature

Useful books for self-study (not mandatory)
Immunology, Kuby et al. 6th edition, 2006, W.H. Freeman & Company Robbins – Pathologic Basic of Disease, 7th edition Schaechter’s Mechanisms of Microbial Disease Microbiology, Prescott (copies will be provided during course for each group)

Information needed:
- Name
- Student number
- BMS programme
- Students.uu.nl email adres
- Background knowledge in the field of I & I

Email this information to k.denzer@umcutrecht.nl