Tuesday 22 January 2013
Immune modulation by neutrophil subsets
Promotor: Prof.dr L. Koenderman
Defence: 22 January 2013
Neutrophils are well known for their pro-inflammatory effects, the clearing of bacteria. But during a human endotoxemia model we identified an anti-inflammatory subset of neutrophils capable of suppressing T-cell proliferation. Knowledge of these suppressive neutrophils could help understand neutrophilic inflammatory diseases like sepsis and Chronic obstructive pulmonary disease. Additionally, in mice models suppressive neutrophils have been described to facilitate cancer growth. Therefore these cells might also be important in human cancer.