Monique van Meegeren
Wednesday 22 August 2012
‘Blood-induced joint damage: novel targets for therapy’
Promotor: Prof. F.P.J.G. Lafeber
Defence: 23 October 2012
Blood-induced joint damage can occur after a major joint trauma or surgery, but also in haemophilia patients. My thesis demonstrated that besides anticoagulated blood (as seen in haemophilia patients) also coagulating blood (as seen in trauma and surgery) degenerates cartilage tissue and causes inflammation of synovial tissue. Treatment with IL-4 and IL-10 protects against this joint damage, but needs to be administered shortly after the joint bleed. In all cases prevention of damage by aspiration of blood from a joint would be the best treatment option. In case of more advanced joint damage, it has been demonstrated that joint distraction improves function and structure of the joint and decreases pain.