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Henk-Jan Prins

Thursday 13 October 2011

Characterization of Mesenchymal Stem Cells with in vivo bone forming capacity-"Bone Building Blocks"

Promotor: Prof. dr P.J. Coffer
Defence: 13 October 2011
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The unique properties of mesenchymal stromal cells (MSCs) make these cells ideal candidates for applications in cellular therapy and to promote the repair of injured tissues, and has led to an enormous increase in their use over the past 20 years. One of these applications is MSC-based bone tissue engineering to heal critical size bone defects, in which success strongly depends on several factors. Among these factors are the quality of the transplanted cells to survive, their potency to differentiate towards bone tissue and thereby replace the damaged tissue, and their ability to attract endogenous resident progenitor cells to home to, and replace the damaged tissue. This thesis describes the investigation of the characteristics of cultured MSC with a special focus on the MSCs with in vivo bone forming capacity.