Utrecht University (logo) (logo)
Universitair Medisch Centrum Utrecht (logo)
You are here: Home > Education > PhD > PhD theses > 2011 > Bardoel

Bart Bardoel

Thursday 22 September 2011

Immune Evasion by Pseudomonal Proteases

Promotor: Prof.dr J.A.G. van Strijp
Defence: 22 September 2011
Full text

Bacteria secrete several proteases that are associated with virulence and modulation of the innate immune response. We identified alkaline proteases of Pseudomonas aeruginosa as an inhibitor of Toll-like receptor 5 and complement activation. Another yet uncharcarterized protease of P. aeruginosa was shown to inhibit PSGL-1-mediated neutrophil recuitment. Furthermore, the staphylococcal protein SSL3 was identified as an inhibitor of Toll-ike receptor 2 activation. All these bacterial proteins assist bacteria to evade recognition by the innate immune system.