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Clarifying protective functions of human natural killer T-cells against development of cardiovascular disease

Friday 18 February 2011

Project
Clarifying protective functions of human natural killer T-cells against development of cardiovascular disease
Recent collaborative work from the Kalkhoven and Boes lab at the UMCU has shown that invariant NKT cells in adipose tissues are protective against the development of insulin resistance, a feature often found associated with development of metabolic syndrome (Schipper HS et al., J. Clin. Invest. 2012). We believe that invariant NKT cells are important mediators of both innate and adaptive immune responses that lie at the interface of metabolic and immune (dys)regulation. In this project, co-supervised by Dr. H.S. Schipper, we address invariant NKT cell mediated mechanisms in the development of cardiovascular disease.
Duration
6 or 9 months

Contact
Marianne Boes, T: 088 75 54982, mail: mboes@umcutrecht.nl