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Role of endosomal antigen sorting of within human dendritic cells in T-cell priming

Friday 18 February 2011

Project
Role of endosomal antigen sorting of within human dendritic cells in T-cell priming
We have shown that remodeling and repositioning of endosomal compartments within dendritic cells is important to T-cell activation. In this project we now try to address whether transport of antigen-specific peptide/MHC complexes is part of this process, in human dendritic cells, and which mechanisms contribute to productive T-cell contact (by tubular endosomes, or exosomes etc.).

Duration
6 or 9 months

Contact
Marianne Boes, T: 088 75 54982 , mail: mboes@umcutrecht.nl