Tuesday 23 November 2010
Induction and maintenance of Bordetella pertussis specific immune responses
Promotor: Prof.dr F. Miedema
Defence: 23 November 2010
Although the importance of both the innate and the adaptive immune system in immunity to pertussis is clearly shown, the exact mechanism and factors that contribute to this immunity have to be further elucidated. Understanding the specificity, magnitude and type of vaccine induced immune mechanisms, including their span of duration and features of fitness or lack of fitness, and any modulatory effects of vaccine antigens, is important for the development of improved vaccines inducing immune responses with a longer duration of protection.
A new challenge in pertussis vaccinology is therefore to identify the natural flaws rather than strengths in pertussis specific immunity (after infection or vaccination), and look out for vaccine candidates inducing long-term immunity at the B cell and/or Th1/Th17-type T cell level, lacking immuno-suppressive features. The studies in this thesis have focused on the immunology of this challenge and thereby adds to the development of pertussis vaccines with longer protection and less adverse immunological reactions in the short as well as in the long run.