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Michael van der Kooij

Monday 17 May 2010

Neuroprotection of the newborn brain: Therapeutic Targets & Behavioral Outcome

Promotor: Prof.dr C.J. Heijnen
Defence: 17 May 2010
Full text

Neonatal hypoxia-ischemia is a considerable clinical problem worldwide for which there is no effective treatment available. Several therapeutics have been shown to reduce the amount of cerebral damage in animal models for neonatal hypoxia-ischemia and therefore are promising for clinical application. Most studies have omitted, however, to demonstate neurofunctional improvements after neurotherapy. The behavioral consequences of neonatal hypoxia-ischemia in rodents and the effect of treatments were central in the current thesis. Using neuroprotective compounds we show that both motor- and cognitive impairments were significantly attenuated.