Michael van der Kooij
Monday 17 May 2010
Neuroprotection of the newborn brain: Therapeutic Targets & Behavioral Outcome
Promotor: Prof.dr C.J. Heijnen
Defence: 17 May 2010
Neonatal hypoxia-ischemia is a considerable clinical problem worldwide for which there is no effective treatment available. Several therapeutics have been shown to reduce the amount of cerebral damage in animal models for neonatal hypoxia-ischemia and therefore are promising for clinical application. Most studies have omitted, however, to demonstate neurofunctional improvements after neurotherapy. The behavioral consequences of neonatal hypoxia-ischemia in rodents and the effect of treatments were central in the current thesis. Using neuroprotective compounds we show that both motor- and cognitive impairments were significantly attenuated.