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Blood-induced joint damage

Thursday 17 January 2013

Prof. dr Floris Lafeber / Lize van Vulpen

Project
Joint bleeds result in joint damage, with characterisitics of both osteoarthritis (degenerative joint disease) as well as of rheumatoid arthritis (inflammatory joint disease).
Joint bleeds can occur due to trauma or joint surgery and are a common phenomenon in patients suffering from the clotting disorder haemophilia. This disease is caused by a deficiency of clotting factor VIII or IX (haemophilia A or B respectively) and spontaneous joint bleeds can occur in these patients.
More insight in the mechanism of the blood-induced arthropathy (joint damage) has been unravaled more and more by research in our department in close collaboration with the Van Creveldkliniek (department of haematology). The presence of erythrocytes and mononucleair cells in the joint cavity lead to the production of radicals that induced death of the cells of the cartilage in the joints. This leads to direct cartilage damage. Futhermore, the synovial tissue gets inflamed, which also contributes to the joint damage.

Within this research project, there are several studies ongoing, that are suitable for an internship. These are amongst others:
- More in depth exploration of the pathogenetic mechanism of blood-induced arthropathy
- In vitro investigation of possible treatment options

Techniques
- Tissue culture (cartilage)
- Biochemical and histochemical analysis of cartilage
- ELISA
- Zymography
- Western Blotting

Duration
6 or 9 months

Contact
Lize van Vulpen, L.F.D.vanvulpen-2@umcutrecht.nl, 088 75 594 28
Prof.dr Floris Lafeber, F.Lafeber@umcutrecht.nl, 088 75 585 21

More information
www.umcutrecht.nl

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