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Inside-out control of human Fc-receptors

Monday 4 May 2009

Prof.dr. Leo Koenderman

Project
Receptors for immunoglobulin receptors are controlled by a control mechanism that allows the cell to induced a fast increase of functionality of these receptors. This process is typically induced by pro-inflammatory mediators. Only after interaction the cells can “see” the targets covered with immunoglobulins. The project focuses on the fundamental processes involved in this control mechanism

Techniques
Cell culture, cell isolation, molecular biological techniques, protein transduction, creation of stable cell lines, several fluorescence techniques including FRAP, FRET and BRET and proteomics.

Duration
9 months

Contact
Prof.dr. Leo Koenderman, l.koenderman@umcutrecht.nl, tel. 088 75 572 55

More info
www.pulmoscience.org

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