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Mahdi Vaezirad

Tuesday 19 September 2017

Campylobacter jejuni strategies to evade hostile environments

Promotor: prof.dr. J.P.M. (Jos) van Putten
Date: 19 September 2017
Time: 12.45 h

Campylobacter jejuni is one of the leading agents in food-borne disease. Despite the lack of most virulence factors, C. jejuni is able to invade the human immune system and evade from chicken immune system. C. jejuni can colonize in chicken ceca (as the main source for human campylobacteriosis) in huge numbers.

In this research we investigated the strategies used by C. jejuni to escape from the immune system, such as the effect of dampening immune system, adjusting pH by bacteria, releasing ammonia to adjusting environment and the interaction between C. jejuni and nitric oxide to change the incidence of protein S-nitrosylation in host.

Most of our findings have been never discussed previously .