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Clinical Immunology

Monday 26 May 2014

BMB-404707

Period: week 37 + 38
ECís: 3

Course description
Deficiency or deregulation of the immune system can lead to a kaleidoscope of clinical features which are genetically determined or induced by infections or cancer therapy.

During this course, lectures and tutorials will focus on four main topics:

1. Immunodeficiencies
2. Autoimmune diseases and atopy
3. Transplantation
4. Tumor Immunology

Course aims and content
Knowledge & insight:
At the conclusion of this course, the student has the ability to...

* Relate immunological principles, clinical consequences, therapies and new evelopments of some disorders (Innate immunodeficiencies and AIDS, Atopy and Autoimmune diseases, Transplantations and Tumor immunology).
* Render examples and principles of animal models, applied to rheumatological research and new therapies in rheumatic disorders.
* Describe the role of regulatory T cells in atopy and autoimmune diseases.
* Explain the mechanisms of (some types of) chronic inflammatory reactions.
* Coherently describe the relationship between tumor and immune system of the host.

Skills:
At the conclusion of this course, the student must be able to present, at the level of a (fledgeling) scientist...

* A coherent, clearly structured, critical survey of one or more scientific articles, which discusses strong and weak points, and proís and conís, of a methodological approach and/or a presented concept.

Attitudes:
At the conclusion of this course, the student must be able to exhibit...

*A critical and inquisitive attitude towards claims concerning animal models and immunopathogenetic concepts.
* A respectful and cooperative attitude towards those with whom the student prepares presentations and conducts discussions.

Literature / study material used

Mandatory:
Immunology: Kuby et al. 6th edition, 2006, W.H. Freeman & Company

Useful other books:
Robbinson - Pathologic Basic of Disease, 7th edition
Alberts - Molecular Biology of the Cell, 4th or 5th edition